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“Gynecomastia” is defined as an abnormal development of the mammary tissue in the male, the result of an alteration in the synthesis of estrogen hormones and testosterone; in general, gynecomastia occurs in the child (pubertal variant) and in the elderly. Although it should not be considered a serious pathology, gynecomastia can cause serious psychological disorders to the subject, who feels different from others, and embarrassed.

In most cases, the cause of gynecomastia resides in hormonal abnormalities: the decrease in serum testosterone levels and the increase in estrogen can increase the volume of one or both breasts. Beyond hormonal factors, gynecomastia can also be heavily influenced by the administration of certain drugs: anabolic, anti-AIDS drugs, anti-androgens, anxiolytics (eg Diazepam), antibiotics, antiulcers, chemotherapeutics and digoxin.

Gynecomastia manifests with a clear swelling of the breasts, associated with pain and secretion of milky substances from one or both nipples. To the touch, the anomalous breast is rather flaccid and obviously swollen.


  • N.B. False gynecomastia occurs when the increase in breast volume depends exclusively on a localized lipid accumulation, in the absence of hormonal alteration or the administration of certain pharmacological specialties.

Information on Gynecomastia – Gynecomastia Drugs is not intended to replace the direct relationship between health professional and patient. Always consult your doctor and / or specialist before taking Gynecomastia – Gynecomastia Drugs.

Numerous cases of gynecomastia regress on their own, without the need to intervene with drugs or surgical treatments; however, if the condition is generated by a specific underlying cause – such as hypogonadism, malnutrition or cirrhosis – it is recommended to promptly intervene on the cause of origin. In the event that the gynecomastia is due to the administration of medicinal specialties, it will be the duty of the doctor to intervene by modifying the treatment with a similar pharmacological substitute.
Normally, pubertal gynecomastia that manifests itself without any obvious cause is not treated with drugs: in fact, the boy is subjected to periodic clinical checks, very useful to monitor the progression or regression of the disease. It is good to remember, in fact, that gynecomastia independent of pathologies or drugs tends to autorisolversi within a few months or a few years (max 2) from its debut.
Pharmacological or surgical treatment is necessary both when the condition does not regress over time (within two years of its onset), or if gynecomastia causes excessive pain or embarrassment.
Among the most used surgical treatments, we remind:

Gynecomastia regression can only occur at puberty: adult men and older adults who experience this disorder will have to undergo pharmacological or surgical intervention to regress the condition.

Below are the classes of drugs most used in gynecomastia therapy, and some examples of pharmacological specialties; it is up to the doctor to choose the active ingredient and dosage most suitable for the patient, based on the severity of the disease, the health status of the patient and his response to treatment:

The drugs used for the treatment of gynecomastia not dependent on secondary pathologies and not spontaneously reversible, are currently few: in any case, it seems that a treatment with tamoxifen and raloxifene – chemotherapeutic drugs with anti-estrogenic activity used for the treatment of Breast cancer – may, in some ways, also alleviate the symptoms of gynecomastia. Although other drugs have been approved by the Food and Drug Administration , their therapeutic effect does not appear to be particularly beneficial for reversing the disease. Sometimes anastrozole is also used. Let’s analyze them in more detail:

       Tamoxifen (eg Nolvadex): the drug performs its therapeutic action by interacting with the estrogen receptor: briefly remember that serum testosterone levels in patients with gynecomastia are low, to the advantage of those of estrogen. Precisely to prevent the link between the receptor and estrogen, this drug is used in therapy for the treatment of gynecomastia (the active ingredient, by binding with the estrogen receptor, prevents the latter from carrying out its activity). The drug can be found in 10 or 20 mg tablets; the dosage and duration of treatment devonor be established by the doctor.

  • Raloxifene (eg Evista): the drug can be used for the treatment of pubertal gynecomastia, where the condition persists for over 2 years. Protect therapy with this drug for 3 to 9 months, depending on the severity of the condition. It is a drug belonging to the class of selective estrogen receptor modulators (SERM); this drug seems to exert a better therapeutic effect to alleviate the signs and symptoms that distinguish gynecomastia. For the dosage: consult the doctor (a drug generally found in 60 mg tablets).
  • Anastrozole (eg Arimidex): it is an aromatase inhibitor, an enzyme involved in the conversion of testosterone (male sex hormone par excellence) into estradiol (the most important human estrogen ever). Starting from this assumption, the drug is also used to treat disorders such as gynecomastia, precisely because it prevents the side effects associated with estrogen superproduction. For the dosage: consult the doctor.

The correction of eating habits is essential when gynecomastia depends on an accumulation of lipids in the breast tissue: localized fat and muscle relaxation are, in this case, the predisposing elements; therefore it is recommended to follow a low-calorie diet, consume a lot of fiber, limit the consumption of meat and practice constant exercise, especially aimed at muscle toning.

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