Health advice: Breast cancer, Tamoxifen and hair loss

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Breast cancer, Tamoxifen, and hair loss – “A woman’s solution!”

Two years ago a beautiful day in late spring, but it soon turned to tragedy for two women (Helen and Denise) in their late 40s when both were diagnosed with invasive cancer
Hormone Hormone Positive for Cancer.The receptors of these two women were very similar. Both were happily married. Both had three children, and both were waiting for full termination. They were two brilliant and ambitious women who, unknowingly, bound themselves together in marriage on that paralyzing spring afternoon.

Both had undergone several lymph node transplants and a lumpectomy. Immediately the effects of 6 weeks of radiotherapy went away. Neither of them had to endure the effects of grueling chemotherapy. Both were determined to defeat this monster that had invaded their bodies. Both bonded as close friends, and when feelings of despair began to creep into their thoughts, they were each other’s confidant to lift their spirits. They were together without ever alerting their relatives to their internal fears that the tumor would return.

After completing treatment, both resumed their daily routine and tried to regain a sense of normalcy in their lives. Both were prescribed Tamoxifen for the next five years. Tamoxifen was very effective in preventing recurrence in invasive hormone-receptor-positive breast cancer. Unbeknownst to Denise, he was not yet done with the problems this demon called cancer had caused her.

Although tamoxifen has some side effects, it is relatively safe, and thousands and thousands of women take it every day without any side effects. Helen barely noticed a change during her treatment with this drug. At first she returned to work part-time, but immediately resumed her role as wife, mother, and full-time employee. One could almost believe that she had ever been treated for cancer, and she was shining again with signs of good health.

Denis, on the other hand, is not equally good. He immediately realized that his hair was starting to fall. Sometimes averaging 200 lines a day. After two weeks on tamoxifen and such rapid hair loss, it was decided to stop taking it. The radiotherapy that was used to save her life left her tired and lethargic. Tamoxifen, which was used to prevent the cancer from returning, was thinning her hair and, above all, destroying her self-esteem.

He researched the prescription drug Rogaine, but found that the chemical name (minoxidil) also had side effects. Rogaine was also very expensive and time-consuming. He envisioned the removal of the ovary. He reasoned that it was positive that his family was complete. He immediately stated that he didn’t think he wanted to undergo multiple surgeries.

He then looked into the FDA’™s approved aromatase inhibitor Aromasin. Aromazine was prescribed to women with early stage disease, but who had already endured 2-3 years of tamoxifen. The following inhibitor, which appeared in the state of Femara. Although it was approved by the FDA to treat early-stage breast cancer, a 5-year course of tamoxifen had to be taken. The third inhibitor was called Ariminex. Prescribed to patients in the early stages of the disease and immediately after surgery. After discussing it with the doctor, she immediately switched from Tamoxifen to Ariminec.

Hair loss was the main reason Denise switched from Tamoxifen to Ariminec. He had no other side effects of this drug, but out of vanity he wanted to keep her from going bald. After taking Ariminex for just under four months, he realized that she had traded the cosmetic effect for the other side, the physical. Denise still had minor hair loss, but now suffered from excruciating joint pain.

The doctor explained that by taking Tamoxifen, your hair loss continued because it could have been caused by the drug giving you an elbow at menopause. Women who have entered menopause sometimes experience hair loss due to decreased estrogen levels. He also explained that everyone has a different tolerance to these products and could have prescribed Femara instead of Ariminex. At this time Denise was taking prolonged-release tramadol for joint pain and feeling exhausted and defeated. She had not yet been able to return to work, even though it had been almost a year since she was first diagnosed with breast cancer.

Financially, Denise and her family were barely making ends meet. Without his much-needed paycheck, bills have piled up. His marriage, once vibrant, began to suffer, and talk of them breaking up was drowned out only by the tears in the eyes of their children. After a year, everything she and her family had worked for seemed ready to collapse!

Denise was still thinking about whether she should start taking Femara or stop taking all her medication altogether.

That morning he received a phone call that changed his life. That was Helen. His confidant in the toughest of times called to see how he was doing. It wasn’t long before Denise emerged from her emotions. Through tears and laughter, Elena and Denise are reunited again, and Denise was no longer in this battle, apparently alone.

Helen, who worked and continues to work in the organic and natural food sector, is saddened that Denise did not trust the precedent of her struggle. She was happy at the thought of being able to help her friend in need.

After listening to Denise’s story, it became clear to Helen that the only side effect of taking Tamoxifen briefly was hair loss. Because of those two simple four letter words (hair loss), the past year had turned into a roller coaster of a downward spiral for Denise and her family.

After a long, detailed conversation with Helen, Denise decided to take her advice and start taking Femara. Shen Minute is an herbal product that literally changed Denise’s life. He interrupted his Ariminex and immediately felt a difference with his joints.After that, she was able to stop taking tramadol for her joint pain because she was no longer in pain. She decided not to start taking Femara, but to resume taking Tamoxifen, since her hair had fallen out after that, and there were no other side effects.

Like Helen, who explained to Denise, Shen Minute Advanced Formula for Women actually prolonged the hair growth stage, thereby reducing the amount of hair that rested and recurred. This herbal supplement has no side effects, and results were found after just one month. A seemingly simple solution, but Denise agonized for almost a year taking medications that led to side effects, unaware that there were natural remedies that could be taken along with conventional medications.

Helen introduced Denise to “Shen Minute,” literally life-changing. It works great with taking tamoxifen with no side effects. Her hair loss is at an acceptably normal level, and she has returned to work full-time. She no longer takes any pain medication, and her marriage is getting stronger and back on track.

Although this story of hair loss from cancer is a little confusing, it is heartfelt. If Denise had known when she would start taking tamoxifen, she would have saved herself months of suffering with severe joint pain due to ariminex. Although the aromatase inhibitor Ariminex is a free side effect for most of her prescribed patients, Denise’s body, for some reason, was unable to tolerate the drug.

The bottom line is that there is no help for those who have lost unwanted hair. Shen Minute offers natural products consisting of capsules, topical formulas and even herbal shampoos that can help with hair loss in both men and women. If you or someone you know suffers from hair loss, even if it is due to genetics, this could be your answer to the problem of thinning hair.

Tamoxifen in the medical therapy of gynecomastia

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Gynecomastia (GM) is a condition of increased breast volume in men that can recognize a variety of clinical conditions 1:

  • – situations dependent on glandular hyperplasia (so-called true GM);
  • – situations where the increase in volume depends on the accumulation of adipose tissue (false GM or lipomastia);
  • – Mixed hyperplasia, with an increase in various proportions of both glandular and fatty components.

The most common situation is pubertal or postpubertal GM, when – usually without identifiable hormonal abnormalities – we observe the development of GM, which tends to regress to acceptable levels within 2 to 3 years after puberty . These situations, also defined as physiological GM, are explained by the hypersensitivity of the mammary gland tissue to stimulation by hormones produced during puberty.

In clinical practice, there are situations (28 to 40%, depending on the series) where the problem is temporally related to the medication intake (See. table). For this reason – especially in adults with a recent problem – a recent pharmacologic history is especially important 2.

Situations due to systemic hormonal changes are in the minority, but initial clinical evaluation should not neglect examination of estradiol, total testosterone, LH, FSH, prolactin and hCG levels to detect hypogonadism, hyperprolactinemia or very rare cases of secretory estrogenic neoplasms or paraneoplastic hCG syndromes.

In most cases where there are no significant hormonal changes and no drug can be traced, the idiopathic condition of GM is due to an increased sensitivity of the breast tissue to circulating estrogens. In these cases, it can lead to persistent situations, sometimes – especially in adolescents – with strong emotional impact: it is usually an aesthetic problem or, less commonly, a painful disorder for which there are few alternatives to surgical resolution 3. Nevertheless, the demand for a nonsurgical approach to achieve the most lasting results with well tolerated and comfortable medications is common.

Because the pathogenesis is explained by an overreaction of estrogen receptors, attention was focused on drugs with anti-estrogenic effects, while dopamine agonist drugs were effective only in cases (a minority) with documented hyperprolactinemia 4 – 5. Experiments with synthetic anti-estrogens used in the 70s (clomiphene and cyclofenil) 6 through 9 have yielded inconsistent results, for which experiments have focused mainly on tamoxifen, a very widely used molecule in hormonal therapy for breast cancer.

Website Tamoxifen is a synthetic non-steroidal molecule belonging to the so-called SERMs (Selective Estrogen Receptor Modulators), drugs that can behave as receptor antagonists in some tissues and agonists in other organs. Tam plays an antagonist role at the breast and bone tissue agonist receptors, whereas at the endometrium it is a partial agonist 10. This drug, because of its anti-estrogenic effect on breast tissue, has been evaluated in numerous studies performed in patients with puberal GM, as well as in patients with GM secondary to medication, especially in cases resulting from treatment with anti-androgens in androgen block in prostate adenocarcinoma.

Overall, published studies present data on 869 patients treated with Tam: most results are from studies in which the drug was used – in idiopathic HM, in men without proven systemic hormonal disease; – in anti-androgen therapy in patients with prostate carcinoma.

In idiopathic GM, the most evaluated dose was 20 mg/day in one or two doses of 11 to 15. Non-significant data – 10 or 40 mg. The duration of the studies varied: with a therapy duration of 3 to 6 months, the result, evaluated clinically or by ultrasound, was found to be favorable in 70 to 80% of cases. Treatment effects are inevitably transient, and in clinical practice, therapy is usually discontinued after 6-8 months, followed by a waiting period to monitor the development of the problem. In cases of relapse, an additional period of treatment is often suggested, but data on this issue from randomized clinical trials are completely lacking. Tamoxifen was generally well tolerated, even at a mongi duration of 16 to 17; side effects noted were mild and only in 6 cases resulted in discontinuation of treatment. No serious adverse events, particularly liver damage or thrombotic episodes, have been reported. Tamoxifen use caused predictable hormonal responses according to its receptor action profile and did not result in changes in hemocoagulation parameters or other risk factors 18 – 19. Efficacy was superior to that of danazol, compared to which Tam is also better tolerated 20. The efficacy of tamoxifen was slightly lower than that of raloxifene in the only comparative study 21.

The efficacy of tamoxifen is clinically more evident and more prolonged in cases of GM secondary to medication 22. The 20 mg/day dose administered to patients with adenocarcinoma of the prostate, operated or unoperated, was effective in both therapy and prevention of GM with bicalutamide 23 – 24. At the same dose, anastrozole 25 – 26 and breast radiotherapy 27 – 28 were also more effective. Tamoxifen treatment was ineffective at a weekly dose of 20 mg after a prior dose of 20 mg/day 29. One study compared prophylactic administration of 10 mg of tamoxifen for one year vs. therapeutic administration of 20 mg with better symptom outcomes in previously treated patients. Treatment with 10 or 20 mg had no significant effect on the course of prostate disease 30. Overall, despite concerns 31 about the overall quality of the studies being very modest (lack of data from randomized and controlled trials, small number of samples studied), the effectiveness of therapy with tamoxifen, appears to derive from the results of all the studies. Several reviews support its use in all types of GM for 3 to 6 months 32 – 34. Given the mechanism of action, it is still important to take a cautious stance in patients still in the growth phase, as the drug may affect long bone maturation.

There is no indication for gynecomastia for any of the treatments described, which is therefore an off-label condition to be prescribed and treated according to the procedures set forth in the Legislative Decree of February 17, 1998, n. 23 when prescribed in group C, except in cases documented and submitted to individual local boards (if any) that may determine grantless dispensing of the drug.